منابع مشابه
Steroidal Hormone Receptor Expression in Male Breast Cancer
Introduction: The etiology of male breast cancer is unclear, but hormonal levels may play a role in development of this disease. It seems that the risk of male breast cancer related to increased lifelong exposure to estrogen or reduced androgen. The aim of this study was to investigate the expression of the steroid hormone receptors including estrogen receptor (ER) and progesterone receptor (PR...
متن کاملA review of estrogen receptor/androgen receptor genomics in male breast cancer.
Male breast cancer is a rare disease, of which little is known. In contrast to female breast cancer, the very vast majority of all cases are positive for estrogen receptor alpha (ERα), implicating the function of this steroid hormone receptor in tumor development and progression. Consequently, adjuvant treatment of male breast cancer revolves around inhibition of ERα. In addition, the androgen ...
متن کاملAndrogen Receptor Expression and Its Correlation with Clinicopathological Parameters in Iranian Patients with Triple Negative Breast Cancer
Background & Objective: Our knowledge about correlation of androgen receptor expression and clinicopathological properties of triple-negative breast cancer (TNBC) patients is inadequate, particularly in the Iranian population. The main aim of the present study was to assess the AR expression in TNBC Iranian patients and evaluate its correlation with their clinicopathological pa...
متن کاملBreast cancer: from estrogen to androgen receptor.
To investigate the link existing between androgens and human breast cancer, the hormonal milieu present in pre- and post-menopausal women has been translated in an in vitro model utilizing a hormone dependent breast cancer cell line MCF-7 exposed to DHEA, DHEAS, androstenediol, T, DHT with or w/o E(2). DHEAS and androstenediol stimulate the growth of MCF-7 cell line but reduce cell proliferatio...
متن کاملsteroidal hormone receptor expression in male breast cancer
introduction: the etiology of male breast cancer is unclear, but hormonal levels may play a role in development of this disease. it seems that the risk of male breast cancer related to increased lifelong exposure to estrogen or reduced androgen. the aim of this study was to investigate the expression of the steroid hormone receptors including estrogen receptor (er) and progesterone receptor (pr...
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ژورنال
عنوان ژورنال: Polish Journal of Pathology
سال: 2015
ISSN: 1233-9687
DOI: 10.5114/pjp.2015.57065